What was the worst pain you can remember? Was it the time you scratched the cornea of your
eye? Was it a kidney stone? Childbirth? Rare is the person who has not experienced some
beyond-belief episode of pain and misery. Mercifully, relief finally came. Your eye
healed, the stone was passed, the baby born. In each of those cases pain flared up in
response to a known cause. With treatment, or with the body's healing powers alone, you
got better and the pain went away. Doctors call that kind of pain acute pain. It is a
normal sensation triggered in the nervous system to alert you to possible injury and the
need to take care of yourself.
Chronic pain is different. Chronic pain persists. Fiendishly, uselessly, pain signals keep
firing in the nervous system for weeks, months, even years. There may been an initial
mishap -- a sprained back, a serious infection -- from which you've long since recovered.
There may be an ongoing cause of pain -- arthritis, cancer, ear infection. But some people
suffer chronic pain in the absence of any past injury or evidence of body damage. Whatever
the matter may be, chronic pain is real, unremitting, and demoralizing -- the kind of pain
New England poet Emily Dickinson had in mind when she wrote:
Pain -- has an Element of Blank --
It cannot recollect
When it begun -- or if there were
A time when it was not
The Terrible Triad
Pain of such proportions overwhelms all other symptoms and becomes the problem. People so
afflicted often cannot work. Their appetite falls off. Physical activity of any kind is
exhausting and may aggravate the pain. Soon the person becomes the victim of a vicious
circle in which total preoccupation with pain leads to irritability and depression. The
sufferer can't sleep at night and the next day's weariness compounds the problem --
leading to more irritability, depression, and pain. Specialists call that unhappy state
the "terrible triad" of suffering, sleeplessness, and sadness, a calamity that
is as hard on the family as it is on the victim. The urge to do something -- anything --
to stop the pain makes some patients drug dependent, drives others to undergo repeated
operations or worse, resort to questionable practitioners who promise quick and permanent
"cures."
"Chronic pain is the most costly health problem in America," says one of the
world's authorities on pain. He and others estimate annual costs, including direct medical
expenses, lost income, lost productivity, compensation payments and legal charges, at
close to $50 billion. Here's how that adds up:
Other pain disorders like the neuralgias and neuropathies that affect nerves throughout
the body, pain due to damage to the central nervous system (the brain and spinal cord), as
well as pain where no physical cause can be found -- psychogenic pain -- swell the total
to that $50 billion figure.
Many chronic pain conditions affect older adults. Arthritis, cancer, angina -- the
chest-binding, breath-catching spasms of pain associated with coronary artery disease --
commonly take their greatest toll among the middle-aged and elderly. Tic douloureux
(trigeminal neuralgia) is a recurrent, stabbing facial pain that is rare among young
adults. But ask any resident of housing for retired persons if there are any tic suffers
around and you are sure to hear of cases. So the fact that Americans are living longer
contributes to a widespread and growing concern about pain.
Neuroscientists share that concern. At a time when people are living longer and painful
conditions abound, the scientists who study the brain have made landmark discoveries that
are leading to a better understanding of pain and more effective treatments.
In the forefront of pain research are scientists supported by the National Institute of
Neurological Disorders and Stroke (NINDS), the leading Federal agency supporting research
on pain. Other Federal agencies important in pain research include the National Institute
of Mental Health (NIMH), the National Institute of Dental Research (NIDR) and the National
Cancer Institute (NCI). Within the last decade both the International Association for the
Study of Pain and the American Pain Society have been established and grown into
flourishing professional organizations attracting young as well as established research
investigators and practicing physicians.
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