Surgery is often considered the court of last resort for pain: When all else fails, cut
the nerve endings. Surgery can bring about instant, almost magical release from pain. But
surgery may also destroy other sensations as well, or, inadvertently, become the source of
new pain. Further, relief is not necessarily permanent. After 6 months or a year, pain may
return.
For all those reasons, the decision for surgery must always involve a careful weighing of
the patient's condition and the outlook for the future. If surgery can mean the difference
between a pain-wracked existence ending in death, versus a pain-free time in which to
compose one's life and see friends and family, then surgery is clearly a humane and
compassionate choice.
There are a variety of operations to relieve pain. The most common is cordotomy: severing
the nerve fibers on one or both sides of the spinal cord that travel the express route to
the brain. Cordotomy affects the sense of temperature as well as pain, since the fibers
travel together in the express route.
Besides cordotomy, surgery within the brain or spinal cord to relieve pain includes
severing connections at major junctions in pain pathways, such as at the places where pain
fibers cross from one side of the cord to the other, or destroying parts of important
relay stations in the brain like the thalamus, and egg-shaped cluster of nerve cells near
the center of the brain.
In addition, surgeons sometimes can relieve pain by destroying nerve fibers or their
parent cell bodies outside the brain or spinal cord. A case in point is the destruction of
sympathetic nerves (a part of the autonomic nervous system) to relieve the severe pain
that sometimes follows a penetrating wound from a sharp instrument or bullet.
When pain affects the upper extremities, or is widespread, the surgeon has fewer options
and surgery may not be as effective. Still, skilled neurosurgeons have achieved excellent
results with upper spinal cord or brain surgery to treat severe intractable pain. These
procedures may employ chemicals or use heat or freezing treatments to destroy tissue, as
well as the more traditional use of the scalpel.
Recently, Harvard Medical School surgeons reported success with a new brain operation
called cingulotomy to relieve intractable pain in patient with severe psychiatric
problems. The nerve fibers destroyed are part of a pathway important in emotions and
motivation. The surgery appears to eliminate the discomfort and suffering the patient
feels, but does not interfere with other mental faculties such as thinking and memory.
Prior to operating, physicians can often test the effectiveness of surgery by using
anesthetic drugs to block nerves temporarily. In some chronic pain conditions -- like the
pain from a penetrating wound -- these temporary blocks can in themselves be beneficial,
promoting repair of nerve damage.
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